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The Health Sciences Group at the National Center for Supercomputing Applications (NCSA) applies advanced computing and information technologies to medicine and public health, including infectious and endemic disease, medical informatics (including algorithmic medicine), clinical and translational science, and disease mapping. After forming in 2005, our first project was designed to meet an immediate need for a large-scale system of medical record documentation and exchange for the medical community working in the aftermath of Hurricane Katrina.